Molecular Details
DICL_CP_0348963
- 5-chloro-N-(2-piperidin-1-ylphenyl)thiophene-2-sulfonamide
Basic Molecular Information
Basic Information
DICL ID
DICL_CP_0348963
PubChem CID
Molecular Formula
C15H17ClN2O2S2 Molecular Weight
356.9 g/mol
Synonyms/Alias
[746609-35-8; 5-chloro-N-(2-piperidin-1-ylphenyl)thiophene-2-sulfonamide; MLS000570381; 5-chloro-N-[2-(1-piperidinyl)phenyl]-2-thiophenesulfonamide; SMR000150436; 5-Chloro-N-(2-(piperidin-1-yl)phenyl)...
InChI Key
RXDWTDRPUXJDPY-UHFFFAOYSA-N
InChI
InChI=1S/C15H17ClN2O2S2/c16-14-8-9-15(21-14)22(19,20)17-12-6-2-3-7-13(12)18-10-4-1-5-11-18/h2-3,6-9,...
IUPAC Name
5-chloro-N-(2-piperidin-1-ylphenyl)thiophene-2-sulfonamide
CAS Number
746609-35-8
Structure Information
Chemical Structure Visualization
SMILES Notation
2D Molecular Drawing
Carbon (C)
Hydrogen (H)
Oxygen (O)
Nitrogen (N)
Sulfur (S)
SDF
39 41 0 0 0 0 0 0 0 0999 V2000
-3.9507 1.6532 -1.5412 C 0 0 0 0 0 0 0 0 0 0 0 0
-3.5067 0.2282 -1.9481 C 0 0 0 0 0 0 0 0 0 0 0 0
-2.0361 -0.060...
Experimental Data
Activity Data
Target Ion Channel
Transient receptor potential channel mucolipin 1 F465L
Uniprot Accession Number
Function
Activator
Species
Homo sapiens (Human)
IC50
N/A (Not available)
EC50
EC50: 640 nM
Ki
N/A (Not available)
Kd
N/A (Not available)
Inhibition
N/A (Not available)
Experimental Conditions
pH
pH 7.4
Holding Potential
−200 to 100 mV mV
Temperature
Room Temperature
Test Method
Patch-clamping
Test Species
HEK293 cell (Homo sapiens embryonic kidney 293 cell)
Binding Information
Binding Site
Extracellular domain
Binding Site Residue
F408Δ, F465L
Disease Information
Related Disease
Not specified
References
Computed Properties
Heavy Atom Count
22
Rotatable Bonds
4
logP
4.1926
Complexity
92.6435
TPSA (Ų)
49.41
H-Bond Donors
1
H-Bond Acceptors
4
Ring Count
3